THE TREATMENT OF SEVERE OR RECURRENT DEEP VENOUS THROMBOSIS - BENEFICIAL EFFECT OF THE COADMINISTRATION OF ANTIPLATELET AGENTS WITH OR WITHOUT RHEOLOGICAL EFFECTS, AND ANTICOAGULANTS

Deep venous thromboses can be divided into two groups according to the ir pathogenesis, anatomical features and differing responses to therap y. The first and most frequent consists of so-called simple venous thr ombosis while the second group, which is less common, comprises severe or recurrent venous thrombosis characterised by a multifactorial path ogenesis, a mixed thrombus rich in platelets and by an incomplete resp onse to both prophylactic and therapeutic treatment with anticoagulant s (heparin or vitamin K antagonist). In a randomized, prospective blin d study in patients with severe or recurrent venous thrombosis, which included 6 groups each of 100 patients, co-administration of anticoagu lants with various types of antiplatelet agent, either with theologica l effects (piracetam, buflomedil, pentoxifylline) or without them (dip yridamole), has shown a beneficial potentiating antithrombotic effect with those drugs possessing rheological effects and the absence of thi s effect with dipyridamole.