ABILITIES OF OSPA PROTEINS FROM DIFFERENT SEROPROTECTIVE GROUPS OF BORRELIA-BURGDORFERI TO PROTECT HAMSTERS FROM INFECTION

Citation
Sd. Lovrich et al., ABILITIES OF OSPA PROTEINS FROM DIFFERENT SEROPROTECTIVE GROUPS OF BORRELIA-BURGDORFERI TO PROTECT HAMSTERS FROM INFECTION, Infection and immunity, 63(6), 1995, pp. 2113-2119
Citations number
43
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
ISSN journal
00199567
Volume
63
Issue
6
Year of publication
1995
Pages
2113 - 2119
Database
ISI
SICI code
0019-9567(1995)63:6<2113:AOOPFD>2.0.ZU;2-8
Abstract
The ability of vaccination with recombinant OspA from six seroprotecti ve groups of Borrelia burgdorferi sensu late to induce protection agai nst infection with homologous and other Lyme spirochetes was examined in hamsters. Antisera generated against the OspA proteins of B. burgdo rferi sensu stricto S-1-10 and C-1-11 (seroprotective groups 1 and 2, respectively), Borrelia afzelii BV1 (seroprotective group 4), and Borr elia garinii LV4 (seroprotective group 5) were able to kill the homolo gous spirochete in vitro but not other isolates. Surprisingly, antiser a against B. afzelii PKo (seroprotective group 6) and B. burgdorferi s ensu late LV5 (seroprotective group 3) OspA proteins were unable to ki ll the homologous organism, although LV5 OspA antisera killed the hete rologous isolates S-1-10 and LV4. In vivo vaccination studies supporte d the in vitro findings, confirming that vaccination with a single Osp A protein does not provide complete protection against challenge with all Lyme disease spirochetes. In addition, OspA antibodies from some i solates may not protect against the homologous isolate. The induction of protective antibodies against other B. burgdorferi proteins may be necessary to insure a comprehensive Lyme disease vaccine.