INSULIN AUTOIMMUNE SYNDROME AFTER THE 3RD THERAPY WITH METHIMAZOLE

In 1986, a 26-year-old female had been diagnosed as having Graves' dis ease and had been treated with methimazole for four months, After the treatment with propylthiouracil for another four months, she had been treated with methimazole once again, She was in complete remission for two years, She again experienced symptoms of hyperthyroidism, and tre atment with methimazole was started again, On the thirteenth day after treatment, she experienced hypoglycemic attacks with skin eruption, T he plasma glucose was 57 mg/dl, I-125-Insulin binding 69%, free IRI 19 6 mu U/ ml. The patient had the HLA-DRB10406.