EFFECT OF ANTI-ICAM-1 AND ANTI-LFA-1 ANTIBODIES ON RAT-LIVER TRANSPLANTATION

The effect of the anti-cell adhesion molecule antibodies anti-ICAM-I ( 1A29) and anti-LFA-1 (WT1), on rat liver transplantation was investiga ted. Livers from ACI rats were transplanted into Lewis rats by Kamada' s method and during the recipient operation 1A29 1 mg/kg, and WT1 1 mg /kg were administered intravenously to one group of rats (treated grou p). The survival time of the treated group was significantly longer th an that of the untreated group, but permanent unresponsiveness could n ot be induced. Postmortem examination revealed little histological evi dence of acute rejection in the treated rats, in which the main cause of death was thought to be chronic rejection.