EVALUATION BY LARVAL RECOVERY OF MEBENDAZOLE ACTIVITY IN EXPERIMENTALMURINE TOXOCARIASIS

We have studied the action of mebendazole on experimental murine toxoc ariasis using different formulations and vehicles. The treatment effic acy was evaluated by larval recovery after digesting several tissues. In the first part of the experiment, the drugs were administered on da ys 1-3 post infection (p.i.) inclusive (hepato-pulmonary phase of the migration), then the animals were sacrificed by the Ist week p.i. In t he second part of the experimental protocol, the treatments were admin istered on days 4-6 p.i. inclusive (myotropic-neurotropic phase of the migration), with sacrifice of the animals by the 7th week p.i. The 2n d pattern of treatment reduced more effectively the total larval recov eries compared with control animals. However, the larval distribution by organs was scarcely affected. The first pattern of treatment reduce d less effectively the total number of larvae, but it significantly in hibited migration.