A PRACTICAL SYNTHESIS OF AN HIV PROTEASE INHIBITOR INTERMEDIATE - DIASTEREOSELECTIVE EPOXIDE FORMATION FROM CHIRAL ALPHA-AMINOALDEHYDES

Authors
NG JS PRZYBYLA CA LIU C YEN JC MUELLNER FW WEYKER CL
Citation
Js. Ng et al., A PRACTICAL SYNTHESIS OF AN HIV PROTEASE INHIBITOR INTERMEDIATE - DIASTEREOSELECTIVE EPOXIDE FORMATION FROM CHIRAL ALPHA-AMINOALDEHYDES, Tetrahedron, 51(23), 1995, pp. 6397-6410
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
23
Year of publication
1995
Pages
6397 - 6410
Database
ISI
SICI code
0040-4020(1995)51:23<6397:APSOAH>2.0.ZU;2-V
Abstract
A practical and efficient synthesis of an HIV protease inhibitor inter mediate has been developed based on the diastereoselective epoxide for mation from a chiral alpha-aminoaldehyde and an in situ generated halo methyllithium reagent.