EPITOPES IN THE 19KDA FRAGMENT OF THE PLASMODIUM-FALCIPARUM MAJOR MEROZOITE SURFACE PROTEIN-1 (PFMSP-1(19)) RECOGNIZED BY HUMAN-ANTIBODIES

Authors
SHAI S BLACKMAN MJ HOLDER AA
Citation
S. Shai et al., EPITOPES IN THE 19KDA FRAGMENT OF THE PLASMODIUM-FALCIPARUM MAJOR MEROZOITE SURFACE PROTEIN-1 (PFMSP-1(19)) RECOGNIZED BY HUMAN-ANTIBODIES, Parasite immunology, 17(5), 1995, pp. 269-275
Citations number
33
Categorie Soggetti
Immunology,Parasitiology
Journal title
Parasite immunology → ACNP
ISSN journal
01419838
Volume
17
Issue
5
Year of publication
1995
Pages
269 - 275
Database
ISI
SICI code
0141-9838(1995)17:5<269:EIT1FO>2.0.ZU;2-G
Abstract
The antibody response to two different epitopes located in the C-termi nal 19 kDa fragment of the Plasmodium falciparum merozoite surface pro tein-1 (MSP-1(19)) has been studied using a competitive ELISA based on the inhibition bf monoclonal antibody (MoAb) binding by serum samples . Sera fi om children aged three to eight years who suffered clinical symptoms of malaria, or were partially immune with an asymptomatic inf ection, and from adults all living in The Gambia, West Africa were tes ted. The results suggest that the antibody response to MSP-1(19) has a role in naturally-acquired immunity in Gambian individuals.