Mj. Kuhn et al., UNILATERAL CEREBRAL CORTICAL AND BASAL GANGLIA ENHANCEMENT FOLLOWING OVERDOSAGE OF NONIONIC CONTRAST-MEDIA, Computerized medical imaging and graphics, 19(3), 1995, pp. 307-311
A 69-year-old woman developed seizures after cerebral angiography imme
diately preceded by coronary angiography. The preceding coronary angio
graphy resulted in hyperconcentration, hyperosmolar loading, and overd
osing of the nonionic contrast medium, A CT examination demonstrated g
yriform enhancement throughout the left cortex and the left basal gang
lia, Preloading with contrast material, as in this case, predisposes t
o disruption of the blood-brain barrier during selective common caroti
d or vertebral artery injection with nonionic contrast.