POTENTIAL CARDIOTOXICITY WITH THE USE OF DUP-941 - A CASE-REPORT

OBJECTIVE: To describe the clinical and pathological features of a:pat ient with probable cardiotoxicity related to a newer chemotherapeutic agent, DuP 941. PATIENT AND METHODS: A 42-year-old woman with metastat ic breast carcinoma treated with only DuP 941 developed, and died of, heart failure for which no other explanation was apparent. RESULTS: Cl inically the patient's heart failure resembled that-associated with an thracycline cardiotoxicity, as did the pathological features seen at a utopsy. CONCLUSION: DuP 941 is a new chemotherapeutic drug that may su pplant some uses of the anthracyclines because the former may have Les s cardiotoxicity. This report suggests that in some cases DuP 941 may have cardiotoxic effects as well.