MATHEMATICAL-MODEL OF THE EFFECT OF MINERAL IMBALANCE ON SINOATRIAL NODE CELLS

This model is organized into three distinct interacting structures: th e extracellular fluid (ECF), the intracellular fluid (ICF), and the in tracellular organelles that represent the calcium pool, Expression of the membrane current between ECF and ICF was the sum of seven ionic ch annels using the Hodgkin-Huxley gating mechanism, three leakage curren ts, Na-Ca exchange, and an electrogenic Na-K pump. Ionic flow between organelles and the ECF was the result of passive diffusion of Mg and C a ions and active transport of Ca-Mg-ATPase. The Potential difference between ECF and sarcoplasmic reticulum was neglected. Using this model , the action potential in normal Tyrode's and various other solutions was simulated.