J. Grabowski et al., FLUOXETINE IS INEFFECTIVE FOR TREATMENT OF COCAINE DEPENDENCE OR CONCURRENT OPIATE AND COCAINE DEPENDENCE - 2 PLACEBO-CONTROLLED, DOUBLE-BLIND TRIALS, Journal of clinical psychopharmacology, 15(3), 1995, pp. 163-174
Cocaine dependence has proved difficult to treat, whether occurring al
one or in combination with opiate dependence. No medication has been d
emonstrated to be uniquely effective. Fluoxetine was examined as a can
didate in two randomized, double-blind, placebo-controlled trials, one
with cocaine-dependent patients (study 1) and the other with patients
both cocaine and opiate dependent (study 2). It was selected for know
n specific action, antidepressant effects, minimum side effects, and d
ata showing reduced cocaine effect and self-administration. Clinic vis
it frequency requirement, a variable with implications for treatment a
nd cost, was also examined in study 1. A total of 228 patients in stud
y 1 and 21 patients in study 2 completed consent and intake procedures
. Patients with serious medical or DSM-III-R diagnoses other than coca
ine dependence (study 1) or opiate and cocaine dependence (study 2)wer
e excluded. Study 1 patients were assigned to one of two visit frequen
cy schedules (2 or 5 days/week) and one of three medication doses (0,
20, or 40 mg of fluoxetine/day). Study 2 patients received placebo or
20 mg of fluoxetine and 65 to 80 mg of methadone and attended the clin
ic 5 days/week. An patients participated in individual therapy session
s. Urine screens were conducted twice weekly. A fluoxetine dose respon
se relationship emerged in study 1 for retention with groups from best
to worst being placebo, 20 mg, and 40 mg. Dose effect order was the s
ame for both visit conditions. Cocaine use persisted in all groups. Th
e two visits/week condition was correlated with better retention than
the five visits/week condition. A significant interaction emerged betw
een intake urine and visit frequency; patients with benzoylecognine sc
reens at intake used cocaine significantly less in the 5 days/week con
dition, while exhibiting no reduction in the 2 days/week condition. Pa
tients cocaine positive at intake were better retained with infrequent
visits. In study 2, a transient reduction in benzoylecognine-positive
drug screens emerged for the fluoxetine group. These complementary st
udies demonstrate that fluoxetine is ineffective in reducing cocaine u
se or craving; Study 1 also points to setting conditions modulating tr
eatment outcome.