INFLUENCE OF SOLUBILIZED COLLAGEN CONCENT RATION ON HYDROLYSIS OF ALPHA-TRICALCIUM BIS(PHOSPHATE)

The alpha-tricalcium bis(phosphate) (alpha-TCP) was hydrolyzed in solu bilized collagen solutions of several collagen concentrations (0.05 to 0.4%) for pH 5 at 30 degrees C for 24 hours. The resulting hydrolyzed products were investigated by X-ray diffraction, Fourier transform in frared spectroscopy, thermal analysis and chemical analysis. The main hydrolyzed products were hydroxyapatite(HAp) and octacalcium dihydroge n hexakis(phosphate) (OCP). The formation of HAp and OCP was accelerat ed in solutions of collagen concentrations over 0.2%. It was suggested that collagen was dispersed uniformly in hydrolyzed products and form ed composite with HAp and OCP by interaction among them. HAp in the hy drolyzed product was nonstoichiometric hydroxyapatite(DAp). As the pro duct contained OCP and collagen in addition to DAp, it might be useful as a raw material of bio-materials.