This article reviews factorial surveys and highlights their utility in
designing intervention programs. It then describes two instances in w
hich factorial surveys were used to develop HIV/AIDS-related intervent
ions: designing HIV vaccine trials that maximize participation and ide
ntifying optimal treatment regimes for HIV positive mothers and their
babies to prevent perinatal HIV infection. We conclude that factorial
survey applications of this kind have a great potential for use in the
design (and redesign where necessary) of intervention programs.