STUDIES ON THE SYNTHESES AND BIOLOGICAL-A CTIVITIES OF TRANS-CYCLOTHIOPHOSPHORYLTHIOUREAS

Thirteen new trans-cyclothiophosphorylthiourea derivatives, R(1)R(2)NC (S) NHR(3) (R(1) = H, alkyl; R(2) = alkyl, substituted phenyl; R(3) = 4-phenyl-5, 5-dimethyl-2-sulfo-1,3,2-dioxaphosphoranyl), were synthes ized by the addition reaction of trans-2-isothiocyano-4-phenyl-5, 5-di methyl-2-sulfo-1,3,2-dioxaphosphorinane to various amines respectively and their structure were confirmed by means of elemental analysis, H- 1 NMR and IR. The biological activities of all new compounds were teds ted preliminarily and the results indicate that some compounds showed fungicidal activity and plant-growth regularity activity. In addition, the stereochemistry of the reaction between 2-chloro-4-phenyl-5, 5-di methyl-2-sulfo-1, 3, 2-dioxaphosphorinane and potassium thiocyanate wa s reported for the first time.