STUDIES ON SEMISYNTHETIC CEPHALOSPORINS A ND PENICILINS DERIVATIVES

Nine derivatives of 7 beta-(5-aryl-2H-tetrazolylacetamido) cephalospor ins were synthesized by acylation of 7 beta-amino group of 7-ACA, 7-AD CA with 5-aryl-2H-tetrazolyacetyl chlorides. In the same way, two new 7 beta (2-phenyl-4-quinolincarboxamido) cephalosporins and two new 6 b eta-acyl-amino penicillins derivatives were obtained. Isolation and pu rification of the thirteen compounds were fulfilled with Sephadex G-15 column chromatography and centrifugal-TLC technique. The structures o f new compounds were confirmed by elementary analysis, IR and H-1 NMR.