A certain number of extracerebral diseases may cause seizures by chang
ing the metabolism of the brain. These diseases include hypoglycemia,
hypoxia, hypocalcemia, uremic and hepatic encephalopathy, various into
xications and hypothyroidism. The diagnosis can be made in most cases
upon results of blood work and urinalysis. Pathogenesis, clinical symp
toms, differential diagnosis, diagnosis as well as treatment and progn
osis of extracerebral diseases are discussed. Approximatively 10 perce
nt of all seizures are due to extracerebral disorders.