POLAROGRAPHIC-BEHAVIOR AND DETERMINATION OF OXAMNIQUINE IN DOSAGE FORMS

A highly sensitive method is described for the determination of oxamni quine in its pure form and in capsules. The proposed method depends up on the polarographic activity of oxamniquine in Britton-Robinson buffe r, whereby a well-defined cathodic wave, followed by a more negative i ll-defined one, was produced over the whole pH range. The first wave w as characterized as being irreversible and diffusion-controlled with l imited absorption properties. The current-concentration relationship w as found to be rectilinear over the ranges 1 x 10(-5) to 5 x 10(-4) an d 1 10(-6) to 5 x 10(-4) M in the direct current (DCT) and differentia l pulse polarography (DPP) modes, respectively, with a minimum detecta bility of 1 x 10(-7) M. The number of electrons involved in the reduct ion process was established through coulometric measurement at an appl ied potential. The mechanism of the electrode reaction was verified an d confirmed through chemical reactions of the electrolyzed solution. T he proposed method was successfully applied to the determination of ox amniquine in capsules, and the results obtained were in accordance wit h those found using the United States Pharmacopeia (USP) XXII method.