NON PHARMACOLOGICAL MODEL OF INHIBITION O F BILE SECRETION BY DEHYDROCHOLIC ACID IN THE RAT - INTEREST AND APPLICATIONS

The aim of this work was to develop a model to study in the rat the in hibitory effect of dehydrocholic acid (DHCA) on the bite secretion and to determine the effects of a dietary treatment, the soya lecithins o n a possible stimulation of bile secretion. DHCA led to a decrease of phospholipid secretion in the bile, dietary lecithins cannot stimulate this secretion. However under DHCA it was shown that biliary secretio n of PC provided by HDL-PC was enhanced by lecithins, compared to cont rol diet. Amount of bile salts increased with DHCA and biliary cholest erol decreased significantly. However in the DHCA group, lecithin incr eased this cholesterol secretion, compared to control diet. This secre tion of biliary lipid, previously inhibited by DHCA, can be enhanced b y lecithins and HDL-PC. Soya lecithins could be considered as an effec tive dietary treatment of liver pathologies linked to decreases of bil e lipid secretion.