RATE OF ONSET AND OFFSET OF 4 NONDEPOLARIZING NEUROMUSCULAR BLOCKING-DRUGS

There is evidence that onset time and potency of non-depolarising neur omuscular blocking drugs are related. The relationship between onset t ime and rate of recovery has not been investigated. In this study, usi ng the isolated forearm technique, the onset time of four different no n-depolarising drugs have been compared with their recovery times. It has been demonstrated that there is a strong relationship between thes e parameters. It is proposed that the relationship between onset time and offset time suggests a common mechanism that influences both event s and that this may also explain the relationship between potency and the rate of onset.