LIPIDOSIS OF THE DORSAL-ROOT GANGLIA IN RATS TREATED WITH AN ALMITRINE METABOLITE

Authors
YAMANAKA Y SAKAMOTO E SAKUMA Y UNO H KOYAMA T IZAWA Y FUJIWARA K
Citation
Y. Yamanaka et al., LIPIDOSIS OF THE DORSAL-ROOT GANGLIA IN RATS TREATED WITH AN ALMITRINE METABOLITE, Archives of toxicology, 69(6), 1995, pp. 391-396
Citations number
36
Categorie Soggetti
Toxicology
Journal title
Archives of toxicology → ACNP
ISSN journal
03405761
Volume
69
Issue
6
Year of publication
1995
Pages
391 - 396
Database
ISI
SICI code
0340-5761(1995)69:6<391:LOTDGI>2.0.ZU;2-Y
Abstract
Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were eva luated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory neurons, satell ite cells, Schwann cells, and vascular endothelial cells of the dorsal root ganglia, The lysosomal lamellated bodies, which were not induced by almitrine, were produced also in cultured rat macrophages exposed to over 1 x 10(-5) M DTMA.