A. Erenmemisoglu et al., PROPHYLACTIC EFFECT OF ORNIDAZOLE ON EXPERIMENTAL TETANUS IN MICE, Drugs under experimental and clinical research, 21(2), 1995, pp. 59-63
Tetanus is still responsible for many deaths, especially in the develo
ping parts of the world. In this study, the prophylactic effect of omi
dazole on experimental tetanus in mice was investigated. The initial m
inimum lethal dose (MLD) of Clostridium tetani spores was determined i
n mice and 100 MLD was applied to mice in experiments. Ornidazole was
then administered at the dose of 20 mg, 40 mg and 80 mg/kg. In additio
n, penicillin and horse tetanus serum were also administered to other
groups. According to the present results, ornidazole decreased the num
ber of deaths in mice significantly in a dose and drug administration
time dependent manner. These results suggest that, together with essen
tial wound care and active immunization, ornidazole (or another nitroi
midazole) may be a useful and supportive therapeutic agent in tetanus
prophylaxis.