POTASSIUM CHANNEL OPENERS - CLINICAL-APPLICATIONS IN ISCHEMIC-HEART-DISEASE - OVERVIEW OF CLINICAL EFFICACY OF NICORANDIL

Authors
KNIGHT C PURCELL H FOX K
Citation
C. Knight et al., POTASSIUM CHANNEL OPENERS - CLINICAL-APPLICATIONS IN ISCHEMIC-HEART-DISEASE - OVERVIEW OF CLINICAL EFFICACY OF NICORANDIL, Cardiovascular drugs and therapy, 9, 1995, pp. 229-236
Citations number
32
Categorie Soggetti
Pharmacology & Pharmacy","Cardiac & Cardiovascular System
Journal title
Cardiovascular drugs and therapy → ACNP
ISSN journal
09203206
Volume
9
Year of publication
1995
Supplement
2
Pages
229 - 236
Database
ISI
SICI code
0920-3206(1995)9:<229:PCO-CI>2.0.ZU;2-W
Abstract
Nicorandil is a balanced arterial and venodilator that may also posses s cardioprotective properties via its activation of ATP-sensitive pota ssium channels. It has a number of beneficial hemodynamic effects and has been shown to be effective in treating angina with similar efficac y as the currently available antianginal agents. In addition, it may h ave useful effects in unstable and variant angina. In this review we e xamine the hemodynamic effects of nicorandil and discuss the currently available data on its clinical efficacy, both in isolation and in com parison with other agents.