A. Chagnac et al., EFFECT OF NIFEDIPINE ON THE RENAL FUNCTIONAL RESERVE IN CYCLOSPORINE-TREATED RENAL-TRANSPLANT RECIPIENTS, Nephron, 70(2), 1995, pp. 207-210
Cyclosporine decreases renal perfusion and impairs the renal hemodynam
ic response to a protein load. High-dose nifedipine has been shown to
elevate renal plasma flow (RPF). We measured the renal functional rese
rve of 6 cyclosporine-treated renal-transplant recipients following in
travenous administration of an amino acid solution, before and 2 weeks
after therapy with high-dose nifedipine (up to 120 mg/day). Pretreatm
ent renal functional reserve was nil. Following administration of nife
dipine, RPF increased by 22% (p < 0.01), filtration fraction decreased
by 14% (p < 0.005) and renal vascular resistance declined by 39% (p <
0.005). Renal functional reserve remained unchanged. High-dose nifedi
pine increases renal perfusion but does not restore renal functional r
eserve in cyclosporine-treated renal-transplant recipients.