EFFECT OF HYPERGLYCEMIA ON GASTRIC-ACID SECRETION AND GASTRIN-RELEASEINDUCED BY INTRAVENOUS AMINO-ACIDS

Intravenous amino acids (IVAAs) are able to stimulate gastric acid sec retion. We investigated the effect of concomitant intravenous infusion of glucose, leading to hyperglycemia, on gastric acid secretion induc ed by IVAAs. Seven healthy volunteers were studied twice, once during normoglycemia and once during acute hyperglycemia with blood glucose c oncentrations stabilized at approximate to 15 mmol/L. Amino acids were infused intravenously at the rate of 10 g/h for 180 min. Acid output was measured by continuous aspiration using a recovery marker. Serum g astrin and plasma pancreatic polypeptide (PP) concentrations were dete rmined at regular intervals. IVVAAs significantly stimulated acid outp ut compared with basal values (2.3 +/- 0.2 and 1.4 +/- 0.4 mmol/15 min , respectively, P < 0.05), release of gastrin, and PP during normoglyc emia. Hyperglycemia completely inhibited (P < 0.05) IVAA-induced gastr ic acid output and significantly inhibited (P < 0.05) release of gastr in and PP. We conclude that IVAAs stimulate gastric acid secretion, an d gastrin and PP release; acute hyperglycemia reduces IVAA-stimulated acid output, and gastrin and PP release; and circulating nutrients inf luence gastric acid and gastrointestinal hormone secretion.