RECIPROCAL MODULATIONS BETWEEN P53 AND TAT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

Authors
LI CJ WANG CL FRIEDMAN DJ PARDEE AB
Citation
Cj. Li et al., RECIPROCAL MODULATIONS BETWEEN P53 AND TAT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, Proceedings of the National Academy of Sciences of the United Statesof America, 92(12), 1995, pp. 5461-5464
Citations number
30
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
92
Issue
12
Year of publication
1995
Pages
5461 - 5464
Database
ISI
SICI code
0027-8424(1995)92:12<5461:RMBPAT>2.0.ZU;2-7
Abstract
Infection by human immunodeficiency virus type 1 (HIV-1) causes acquir ed immunodeficiency syndrome (AIDS) after a long clinical latency. Thi s disease is associated with a spectrum of cancers. Here we report tha t wild-type p53 is a potent suppressor of Tat, a major transactivator of HIV-1. Reciprocally, Tat inhibits the transcription of p53. Downreg ulation of p53 by upregulated tat may be important for the establishme nt of productive viral infection in a cell and also may be involved in the development of AIDS-related malignancies.