THE EFFECTS OF INFUSION OF TRIEICOSAPENTAENOYL-GLYCEROL EMULSION ON EXTRAVASCULAR LUNG WATER DURING MYOCARDIAL-ISCHEMIA AND REPERFUSION IN DOGS

To test the effects of eicosapentaenoic acid (EPA) infusion on pulmona ry edema induced by coronary ligation and reperfusion, extravascular l ung water (EVLW) was measured in situ by the thermal-dye double indica tor dilution method in dogs. In the control group of five dogs, 30 mt of a 10% soybean oil emulsion was infused through a leg vein. One hour after infusion, the left anterior descending coronary artery below th e first diagonal branch was ligated for 15 min and then reperfused for 30 min. In the EPA group, six dogs were similarly treated with an emu lsion of a 10% trieicosapentaenoyl-glycerol (90% pure). EVLW, pulmonar y capillary wedge pressure, mean pulmonary artery pressure, mean blood pressure, and cardiac index were measured before and 15 min after cor onary ligation, and 15 min and 30 min after coronary reperfusion. Ther e were no significant differences in the hemodynamic indices between t he two groups. EVLW significantly increased up to two times of baselin e during coronary ligation in the control group (P < 0.05) and more du ring reperfusion (P < 0.01), whereas EVLW did not increase in the EPA group. In conclusion, EPA inhibited EVLW accumulation and may be usefu l for ameliorating one of the ischemia-reperfusion-induced complicatio ns, pulmonary edema.