PATHOGENETIC ASPECTS OF MEASLES-VIRUS INFECTIONS

In this review we briefly summarise virological and immunological aspe cts of acute and persistent measles virus (MV) infections as found in man and further investigated in animal models and tissue culture. Seve ral mechanisms contributing to MV persistence are discussed. Recent fi ndings, especially the analysis of CD46 and moesin as receptor acting molecules for MV, correlate well with the tropism of MV and open new f ields for the investigation of MV associated immunosuppression and cen tral nervous system (CNS) complications.