Pj. Schuil et al., EFFECTS OF PROSTAGLANDINS D-2 AND E(2) ON CILIARY BEAT FREQUENCY OF HUMAN UPPER RESPIRATORY CILIA IN-VITRO, Acta oto-laryngologica, 115(3), 1995, pp. 438-442
Diminished mucociliary transport can occur in a type-I (Ig-E mediated)
allergic reaction. We determined the effects of the allergy mediators
prostaglandin D-2 (PGD(2)) and prostaglandin E(2) (PGE(2)) on the cil
iary beat frequency (CBF) of human upper respiratory cilia in vitro. H
uman adenoid tissue was used as the source for ciliated epithelium. CB
F was measured by a computerized photo-electric method. PGD(2) (10(-8)
-10(-5) M, n = 7) showed no statistically significant effect on CBF. P
GE(2) (10(-9)-10(-6) M, n = 10) caused a significant dose-dependent st
imulation, with a maximum of 37% (ANOVA, p < 0.001). Thus prostaglandi
ns D, and E, do not exert a direct negative influence on ciliary activ
ity, which could account for a decrease in mucociliary transport. The
stimulating effect of PGE, may be relevant in promoting mucociliary cl
earance in vivo.