The effectiveness of botulinum toxin injections for the management of
Frey's syndrome was studied. Botulinum toxin A (similar to 0.5 Units/c
m(2)) was injected intracutaneously into the affected skin area as det
ermined by Minor's starch iodine test. Gustatory sweating in the treat
ed skin area ceased completely within 1 week and has not reappeared (1
2 months follow up until now in the first treated case). There have be
en no side effects. It is concluded that local botulinum toxin injecti
ons are a highly effective and safe treatment for Frey's syndrome. Add
itional study is required to evaluate the duration of the therapeutic
effect.