PROMOTION BY SR-48692 OF GASTRIC-EMPTYING AND DEFECATION IN RATS SUGGESTING A ROLE OF ENDOGENOUS NEUROTENSIN

Authors
CROCI T GIUDICE A MANARA L GULLY D LEFUR G
Citation
T. Croci et al., PROMOTION BY SR-48692 OF GASTRIC-EMPTYING AND DEFECATION IN RATS SUGGESTING A ROLE OF ENDOGENOUS NEUROTENSIN, British Journal of Pharmacology, 115(3), 1995, pp. 383-384
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
115
Issue
3
Year of publication
1995
Pages
383 - 384
Database
ISI
SICI code
0007-1188(1995)115:3<383:PBSOGA>2.0.ZU;2-U
Abstract
We investigated the influence of the nonpeptide neurotensin receptor a ntagonist, SR 48692, administered orally, on gastric emptying and on a cute defaecation. SR 48692 dose-dependently (ED(50) similar to 0.7 mu g kg(-1)) increased gastric emptying of a food suspension, but it had no effect on that of a non-caloric meal. SR 48692 also dose-dependentl y promoted defaecation and increased faecal water content. We suggest that antagonism of endogenous neurotensin accounts for the gastric emp tying and defaecation promoting action of SR 48692.