S. Goerdt et al., LEUKEMIA-CUTIS LOCALIZING TO PREEXISTENT HYPERLIPIDEMIC XANTHELASMATAPALPEBRARUM, EJD. European journal of dermatology, 5(3), 1995, pp. 234-236
We report on a patient in whom leukemia cutis developed exclusively wi
thin pre-existent hyperlipidemic xanthelasmata palpebrarum during the
blast crisis of a myelodysplastic syndrome. Immunophenotyping of the x
anthelasma macrophages revealed an alternative activation state compat
ible with the secretion of angiogenic factors and preferential adhesio
n of leukemic leukocytes to lesional endothelium.