TOPICAL TREATMENT OF POSTVITRECTOMY FIBRIN FORMATION WITH TISSUE-PLASMINOGEN ACTIVATOR

Tissue plasminogen activator (tPA) is able to dissolve any fibrin mate rial that forms in the anterior chamber or vitreous humor. This proper ty has been reported by various experimental studies performed in rabb its. The authors demonstrate the tPA eye drops administered to patient s with postoperative hyphema, which did not respond to traditional the rapy, gave rapid clearance of the clot. Following its topical administ ration for the first time in patients, the harmless nature of the drug is emphasized as well as its efficacy. This study indicates the promi sing features of this drug which deserve further investigation.