When trying to assess the implications of recent deep shifts in the ph
ilosophy of science for the broader arena of medicine, the theme that
most readily comes to mind is underdetermination. In scientific resear
ch one always hopes for determination: that the world should determine
the observations we make of it; that evidence should determine the th
eories we adopt; that the practice of science should determine results
independent of the sort of society in which that practice takes place
. In this essay, doubts cast on each of these ideas by recent work in
philosophy of science will be discussed and the consequences for philo
sophy of medicine will be indicated.