THE MODIFICATION OF BLOOD-FLOW IN TUMORS AND THEIR SUPPLYING ARTERIESBY NICOTINAMIDE

We have studied the ability of the radiosensitizer nicotinamide (NA) t o alter the contractility of normal and tumour blood vessels using an ex vivo isolated artery perfusion system. NA at a concentration of 8.2 mM reduced the constrictions produced by phenylephrine (PE) by 2-fold in both normal epigastric arteries and those that had been supplying p22 tumours in BD9 rats. At that same concentration NA also attenuated the spontaneous, rhythmic contractions that were seen in many tumour arteries. When the tumour arteries were perfused together with the tum our they supplied NA had little effect on the flow resistance of the t umour vascular network but reduced the resistance by up to 30% when th e arteries were preconstricted with phenylephrine. These direct effect s on vascular resistance together with the reduction of interstitial f luid pressure could combine to improve the homogeneity of tumour perfu sion.