TRABECULECTOMY WITH MITOMYCIN-C - A STUDY OF 30 CASES

Standard trabeculectomy with adjunct Mitomicyn C application was perfo rmed in 30 eyes of 26 patients with refractory glaucoma to study the e fficacy and safety of this technique. The results were analyzed fop ea ch aetiology and number of ocular risk factors for failure of filterin g procedure and compared with those of others series, including those using 5-fluorouracil. Methods The surgical procedure was similar to th at described by Cairns, except that a fornix-based conjunctival flap w as used. A 0.4 mg/ml solution of Mitomycin C was applied at the filtra tion site ibv three minutes. The mean follow-up was 6.4 months; the th irty eyes were followed for 4 to II months. Results At 6 months, the i ntraocular pressure was less than 21 mmHg in 65.2% of cases without po stoperative glaucoma medication, and the overall success rate was 86.9 %. No remarkable complications occurred. Conclusion Intraoperative Mit omycin C may be a helpful adjunct in achieving low final intraocular p ressure after trabeculectomy in high-risk glaucoma filtering surgery, and Mitomycin C may be a viable alternative to postoperative 5-Fluorou racile. But further studies regarding late complications due to mitomy cin are required.