DETERMINATION OF FLUCONAZOLE CONCENTRATIONS IN THE PROSTATIC AND SEMINAL-VESICLE FLUID (SPLIT EJACULATE)

The concentrations of fluconazole, a systemic antifungal agent, were d etermined in the split ejaculate of seven healthy volunteers. Followin g once-daily oral administration of fluconazole 200 mg over a period o f 5 days, the fluconazole levels were determined in ejaculate samples which had been divided into two consecutive fractions upon collection. Simultaneously, a blood sample was drawn for the determination of flu conazole serum levels. It was shown that the fluconazole concentration s determined in both ejaculate fractions corresponded to those found i n the serum. As the first fraction of the ejaculate originates in the prostate, the prostatic fluconazole concentrations are likely to be si milar to the fluconazole levels found in the ejaculate.