AMPHOTERICIN-B FOLLOWED BY ITRACONAZOLE IN THE TREATMENT OF DISSEMINATED FUNGAL-INFECTIONS IN NEUTROPENIC PATIENTS

The role of the new triazoles in the treatment of disseminated fungal infections in neutropenic patients is at present under scrutiny. Six n eutropenic patients with disseminated fungal infections were treated w ith amphotericin B during neutropenia and itraconazole after bone marr ow recovery. There were three pulmonary aspergillomas, one Aspergillus fumigatus sinusitis, one Fusarium-mycosis and one disseminated candid osis. Four patients were cured of the infection. This approach seems t o be safe and effective in the treatment of disseminated fungal infect ions in neutropenic patients, with the advantages of low side-effects and the possibility of early discharge from hospital.