M. Nucci et al., AMPHOTERICIN-B FOLLOWED BY ITRACONAZOLE IN THE TREATMENT OF DISSEMINATED FUNGAL-INFECTIONS IN NEUTROPENIC PATIENTS, Mycoses, 37(11-12), 1994, pp. 433-437
The role of the new triazoles in the treatment of disseminated fungal
infections in neutropenic patients is at present under scrutiny. Six n
eutropenic patients with disseminated fungal infections were treated w
ith amphotericin B during neutropenia and itraconazole after bone marr
ow recovery. There were three pulmonary aspergillomas, one Aspergillus
fumigatus sinusitis, one Fusarium-mycosis and one disseminated candid
osis. Four patients were cured of the infection. This approach seems t
o be safe and effective in the treatment of disseminated fungal infect
ions in neutropenic patients, with the advantages of low side-effects
and the possibility of early discharge from hospital.