GENETIC APPROACHES TO NUCLEAR-PORE STRUCTURE AND FUNCTION

Authors
DOYE V HURT EC
Citation
V. Doye et Ec. Hurt, GENETIC APPROACHES TO NUCLEAR-PORE STRUCTURE AND FUNCTION, Trends in genetics, 11(6), 1995, pp. 235-241
Citations number
45
Categorie Soggetti
Genetics & Heredity
Journal title
Trends in genetics → ACNP
ISSN journal
01689525
Volume
11
Issue
6
Year of publication
1995
Pages
235 - 241
Database
ISI
SICI code
0168-9525(1995)11:6<235:GATNSA>2.0.ZU;2-5
Abstract
The major features of nucleocytoplasmic transport through nuclear pore complexes are conserved from yeast to humans. This transport machiner y, which includes the 125 MDa nuclear pore complex structure, has been molecularly dissected in the yeast Saccharomyces cerevisiae by geneti c approaches. Here, we summarize the genetic analyses used to elucidat e structure-function relationships within this large supramolecular as sembly.