Background: This study identified factors associated with medically se
rious suicide attempts (requiring medical hospitalization). Method: De
mographic information, current psychiatric mental state, suicide attem
pt and psychiatric history characteristics, and DSM-IV diagnoses were
compared between 65 patients hospitalized for a medically serious suic
ide attempt (MSSA) and 32 patients seen in the emergency room for suic
ide attempt but not medically hospitalized (NMSSA). Results: Those wit
h MSSAs had a higher rate of substance-induced mood disorder (but not
substance abuse or dependence), while those with NMSSA had more attemp
ts, more years since first attempt, and a higher rate of sexual and ph
ysical abuse, traumatic life events, borderline personality disorder,
and bipolar disorder. Conclusion: Substance-induced mood disorder is a
n important diagnosis in the evaluation of suicidal patients. The vuln
erability of mood effects caused by substance abuse may lead to a more
serious suicide attempt despite less extensive psychiatric problems.
The most important early psychiatric intervention may be the immediate
recognition and aggressive treatment of an individual's affective and
substance use disorders,