Item bias (differential item functioning) analysis examines whether th
e construction of an index from two or more variables results in bias
in relation to sex, age, or other criteria. Item bias may lead to erro
neous conclusions because of distortion or dilution of the effects mea
sured. In comparing groups, item bias analysis, tests whether the info
rmation about possible differences between groups, obtained by the var
iables constituting an index, are correctly passed on by the index sco
re. We examined a quality of life questionnaire answered by 1189 breas
t cancer patients. We found age-bias or bias in the comparison of grou
ps receiving different treatments in three out of nine indexes. Recomm
endations for the interpretation of these indexes are made. Item bias
analysis is a useful method examining an issue not covered by traditio
nal psychometric tests.