INSULIN-RECEPTORS ON THE ENDOLYMPHATIC SAC - AN AUTORADIOGRAPHIC STUDY

Authors
KNIGHT LC SAEED SR HRADEK GT SCHINDLER RA
Citation
Lc. Knight et al., INSULIN-RECEPTORS ON THE ENDOLYMPHATIC SAC - AN AUTORADIOGRAPHIC STUDY, The Laryngoscope, 105(6), 1995, pp. 635-638
Citations number
15
Categorie Soggetti
Otorhinolaryngology,"Instument & Instrumentation
Journal title
The Laryngoscope → ACNP
ISSN journal
0023852X
Volume
105
Issue
6
Year of publication
1995
Pages
635 - 638
Database
ISI
SICI code
0023-852X(1995)105:6<635:IOTES->2.0.ZU;2-5
Abstract
Light microscopic autoradiographs were prepared of isolated guinea pig endolymphatic sac (ES) tissue incubated with iodine (I)-125-labeled i nsulin (insulin I 125). These demonstrated specific binding of the ins ulin I 125 to receptors in the ES. Receptor-mediated endocytosis of th e insulin-receptor complex is postulated to occur, and the relevance o f insulin receptors in the ES is discussed, with particular emphasis o n the previously observed synthesis of hyaluronan from glucose by the ES.