LONG-TERM FOLLOW-UP OF A 4-YEAR-OLD BOY W ITH RECURRENT HYPOGLYCEMIA AND CHOLESTASIS IN CONGENITAL GROWTH-HORMONE DEFICIENCY

We report on a four-year-old boy with congenital growth hormone defici ency who first presented at age 13 weeks with jaundice and recurrent h ypoglycemia. Growth hormone deficiency was diagnosed two years later, after cholestasis and hypoglycemia had almost completely disappeared, but length deficiency became apparent. The reason for the association of cholestasis with growth hormone deficiency remains unexplained. Cho lestasis can, especially in combination with hypoglycemia, be a first sign of congenital growth hormone deficiency.