Although extraocular muscle is perhaps the least understood component
of the oculomotor system, these muscles represent the most common site
of surgical intervention in the treatment of strabismus and other ocu
lar motility disorders. This review synthesizes information derived fr
om both basic and clinical studies in order to develop a better unders
tanding of how these muscles may respond to surgical or pharmacologica
l interventions and in disease states. In addition, a detailed knowled
ge of the structural and functional properties of extraocular muscle,
that would allow some degree of prediction of the adaptive responses o
f these muscles, is vital as a basis to guide tile development of new
treatments for eye movement disorders.