Se. Berning et al., LONG-TERM SAFETY OF OFLOXACIN AND CIPROFLOXACIN IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS, American journal of respiratory and critical care medicine, 151(6), 1995, pp. 2006-2009
Citations number
16
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
Ofloxacin and ciprofloxacin are potentially useful agents for treating
mycobacterial infections. We retrospectively reviewed 7 years' experi
ence with these agents in 103 patients, Ofloxacin was used primarily t
o treat tuberculosis (TB), dosed to achieve 2-hour postdose serum conc
entrations of 8-12 mu g/ml. Ciprofloxacin was used primarily to treat
Mycobacterium avium complex (MAC) infection, dosed to achieve 2-hour p
ostdose serum concentrations of 4-6 mu g/ml. Despite differences in pa
tient characteristics, underlying disease, and concurrent medications,
ofloxacin and ciprofloxacin were associated with a similar spectrum a
nd incidence of adverse reactions. Both drugs were generally well tole
rated. Adverse effects led to an ofloxacin dosage change in 1 patient
(3%) and discontinuation of ofloxacin in 2 patients (6%). Adverse effe
cts led to a ciprofloxacin dosage change in 2 patients (3%) and discon
tinuation of ciprofloxacin in 5 patients (7%). Ofloxacin and ciproflox
acin appear to be tolerated as well as or better than other ''second-l
ine'' antimycobacterial drugs.