VALIDATION OF THE LIMULUS AMEBOCYTE LYSATE (LAL) TEST FOR ROUTINE PETRADIOPHARMACEUTICALS

Authors
ZIJLSTRA S GERKEN P RECHIN C WORTMANN R NOTOHAMIPRODJO G
Citation
S. Zijlstra et al., VALIDATION OF THE LIMULUS AMEBOCYTE LYSATE (LAL) TEST FOR ROUTINE PETRADIOPHARMACEUTICALS, Applied radiation and isotopes, 48(1), 1997, pp. 51-54
Citations number
8
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging","Chemistry Inorganic & Nuclear
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
48
Issue
1
Year of publication
1997
Pages
51 - 54
Database
ISI
SICI code
0969-8043(1997)48:1<51:VOTLAL>2.0.ZU;2-F
Abstract
The kinetic turbidimetric limulus amebocyte lysate test was validated as method for detecting endotoxins in short-lived radiopharmaceutical samples. Using this method, radiopharmaceuticals can be released for a dministration to humans after the test, without extensive loss of radi oactivity. Inhibition or enhancement on the LAL results by the product samples were examined in more detail and eliminated. Copyright (C) 19 97 Elsevier Science Ltd