GYNECOLOGICAL COMPLICATIONS OF WOMEN TREATED WITH TAMOXIFEN FOR BREAST-CANCER

We present 6 cases illustrating some of the gynaecological complicatio ns associated with tamoxifen treatment of women with breast cancer. Th e first 2 represent cases of myometrial hypertrophy secondary to tamox ifen use, a postmenopausal woman and a premenopausal women with recurr ent carcinoma of the breast. The third is a case of probable ovulation induction in a perimenopausal woman with recurrent breast cancer who was commenced on tamoxifen 20 mg daily. The other 3 cases illustrate s ome of the endometrial effects associated with tamoxifen therapy in wo men with a history of breast cancer, namely cystic glandular hyperplas ia, endometrial polyps and endometrial cancer.