The principal features of POEMS syndrome are osteosclerotic bone lesio
ns. peripheral sensorimotor neuropathy, and elevated levels of a monoc
lonal protein in the serum or urine, Skin lesions are present in the m
ajority of patients with POEMS syndrome, Diffuse hyperpigmentation is
the most common cutaneous finding, Hemangiomas with histopathological
features resembling renal glomeruli are the most specific skin lesions
. (C) 1995 by W.B. Saunders Company