THE 8-KD PRODUCT OF THE PUTATIVE ONCOGENE MTCP-1 IS A MITOCHONDRIAL PROTEIN

Authors
MADANI A SOULIER J SCHMID M PLICHTOVA R LERME F GATEAUROESCH O GARNIER JP PLA M SIGAUX F STERN MH
Citation
A. Madani et al., THE 8-KD PRODUCT OF THE PUTATIVE ONCOGENE MTCP-1 IS A MITOCHONDRIAL PROTEIN, Oncogene, 10(11), 1995, pp. 2259-2262
Citations number
25
Categorie Soggetti
Genetics & Heredity",Oncology
Journal title
Oncogene → ACNP
ISSN journal
09509232
Volume
10
Issue
11
Year of publication
1995
Pages
2259 - 2262
Database
ISI
SICI code
0950-9232(1995)10:11<2259:T8POTP>2.0.ZU;2-G
Abstract
An unusually small (8 kD) protein (p8(MTCP-1)) is coded by the putativ e oncogene MTCP-1 (also called c6.1B), involved in the translocation t (X;14)(q28;q11) associated with some mature T-cell proliferations. Her e, we show by subcellular fractionation and by confocal microscopy tha t this protein is located in the mitochondria. This localization orien tates toward a role of p8(MTCP-1) in the mitochondrial metabolism whic h may be relevant for the oncogenic process.