SUSCEPTIBILITY OF ENCEPHALITOZOON-CUNICULI TO SEVERAL DRUGS IN-VITRO

In the light of the increased incidence of human Encephalitozoon infec tions and the absence of an established treatment protocol, a simple i n vitro testing method to compare activities of drugs against Encephal itozoon cuniculi was developed. With this in vitro method, the 50% inh ibitory concentrations of fumagillin, thiabendazole, albendazole, oxib endazole, and propamidine isethionate for E. cuniculi in rabbit kidney cells were determined. Itraconazole, toltrazuril, metronidazole, roni dazole, and ganciclovir were ineffective in this testing system.