EVALUATION OF SCH51048 IN AN EXPERIMENTAL-MODEL OF PULMONARY ASPERGILLOSIS

The efficacy of a novel triazole, SCH51048, was assessed with a murine model of pulmonary aspergillosis and was compared with those of SCH39 304 and itraconazole. A wide range of doses of SCH51048 (5 to 50 mg/kg of body weight) was evaluated. Mortality was significantly delayed in mice treated with doses of 5 mg of SCH51048 per kg or greater in comp arison with mortality in controls (P < 0.05). Both SCH51048 and SCH393 04 at higher doses (30 and 50 mg/kg) reduced the number of viable Aspe rgillus fumigatus organisms in lung tissue (P < 0.05). In the present model, itraconazole neither delayed mortality nor significantly reduce d the counts in tissue at the doses used, We conclude that SCH51048 is an effective therapy for murine pulmonary aspergillosis.